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Molecular authentication of the traditional Chinese medicine Tongren Dahuoluo Wan and its alternative

Jikun WANG, Jing DU, Meng CAO, Lu YAO, Suhua XIE, Jiafu CHEN, Xingbo ZHAO

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 353-357 doi: 10.15302/J-FASE-2017157

Abstract: To develop a simple and reliable molecular method for authenticating the two patent medicines, mitochondrialFor the patent medicine authentication, we set up a molecular diagnostic assay to resolve the difficultiesorigins in traditional Chinese medicine, and discuss the experimental solutions for technical problems of moleculardiagnostic assays.

Keywords： Tongren Dahuoluo Wan     molecular diagnostic assay     Eospalax baileyi     Panthera pardus     species-specific    

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Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 157-175 doi: 10.1007/s11684-021-0884-z

Abstract: In this review, the latest advances of biosensors regarding the assay of exosomes were summarized, and

Keywords： biosensor     exosome     cancer diagnosis    

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Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 723-735 doi: 10.1007/s11684-021-0905-y

Abstract: Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease. At present, no definite ALS biomarkers are available. In this study, exosomes from the plasma of patients with ALS and healthy controls were extracted, and differentially expressed exosomal proteins were compared. Among them, the expression of exosomal coronin-1a (CORO1A) was 5.3-fold higher than that in the controls. CORO1A increased with disease progression at a certain proportion in the plasma of patients with ALS and in the spinal cord of ALS mice. CORO1A was also overexpressed in NSC-34 motor neuron-like cells, and apoptosis, oxidative stress, and autophagic protein expression were evaluated. CORO1A overexpression resulted in increased apoptosis and oxidative stress, overactivated autophagy, and hindered the formation of autolysosomes. Moreover, CORO1A activated Ca2+-dependent phosphatase calcineurin, thereby blocking the fusion of autophagosomes and lysosomes. The inhibition of calcineurin activation by cyclosporin A reversed the damaged autolysosomes. In conclusion, the role of CORO1A in ALS pathogenesis was discovered, potentially affecting the disease onset and progression by blocking autophagic flux. Therefore, CORO1A might be a potential biomarker and therapeutic target for ALS.

Keywords： amyotrophic lateral sclerosis     coronin-1a     autophagy     pathogenesis    

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Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 129-133 doi: 10.1007/s11684-015-0387-x

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Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 109-114 doi: 10.1007/s11684-007-0021-7

Abstract: The overall diagnostic capabilities and utility of frequency-doubling technology (FDT) in patients withCriteria for inclusion or exclusion were established according to validity criteria for diagnostic studiespublished by the Cochrane Methods Group on Screening and Diagnostic Tests.The included articles are of good quality and FDT can be a highly efficient diagnostic test for primary

Keywords： inclusion     sensitivity analysis     correction     specificity     appropriate    

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Development and application of reconfigurable monitoring and diagnostic system oriented to machine tool

Jing Minqing,Li Meng,Liu Heng

Strategic Study of CAE 2013, Volume 15, Issue 1,   Pages 34-38

Abstract: quot;system engine + function component" architecture for the reconfigurable monitoring and diagnosticThis paper has also developed a series of regular monitoring and diagnostic components for computer numericalThen the monitoring and diagnostic system for specific machine tools, which has been running in

Keywords： monitoring and diagnostic system for machine tool     reconfigurable     system engine     function component    

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Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 157-160 doi: 10.1007/s11684-007-0029-z

Abstract: This study aims to investigate the clinical response of ATP tumor chemosensitivity assay (ATP-TCA) directedThis tissue was put through the assay to determine chemosensitivity.
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Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 148-152 doi: 10.1007/s11684-009-0032-7

Abstract: amplified by polymerase chain reaction (PCR) and cloned into pGL3-basic vector and pEGFP-1 vector to assayThe promoter transcription activity was determined by dual-luciferase report assay, and enhanced greenThe dual-luciferase reporter assay showed that the promoter transcription activity in digestive system

Keywords： gene     X-linked inhibitor of apoptosis protein associated factor-1 (XAF1)     promoter     transcription regulation    

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An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 506-509 doi: 10.1007/s11684-013-0294-y

Abstract:

This study aimed to investigate patient dose in diagnostic screen-film radiographic examinations in

Keywords： radiation dosage     radiology     radiation protection     radiography/statistics & numerical data    

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Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 243-247 doi: 10.1007/s11684-012-0201-y

Abstract: Although it has been reported for about 20 years, the diagnostic criteria of this disease remain controversialHere, we aim to review and discuss the diagnostic criteria of latent autoimmune diabetes in adults.

Keywords： LADA     diagnostic criteria     autoantibodies     insulin independence     age of diagnosis    

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treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 827-858 doi: 10.1007/s11684-022-0948-8

Abstract: Infertility is experienced by 8%–12% of adults in their reproductive period globally and has become a prevalent concern. Besides routine therapeutic methods, stem cells are rapidly being examined as viable alternative therapies in regenerative medicine and translational investigation. Remarkable progress has been made in understanding the biology and purpose of stem cells. The affected pluripotent stem cells (iPSCs) and mesenchymal stem cells (MSCs) are further studied for their possible use in reproductive medicine, particularly for infertility induced by premature ovarian insufficiency and azoospermia. Accordingly, this study discusses current developments in the use of some kinds of MSCs such as adipose-derived stem cells, bone marrow stromal cells, umbilical cord MSCs, and menstrual blood MSCs. These methods have been used to manage ovarian and uterine disorders, and each technique presents a novel method for the therapy of infertility.

Keywords： infertility     stem cell therapy     mesenchymal stem cells     pluripotent stem cells    

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An extraction- assay system: Evaluation on flavonols in plant resistance to Pb and Cd by supercritical

Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui

Frontiers of Environmental Science & Engineering 2018, Volume 12, Issue 4, doi: 10.1007/s11783-018-1059-2

Abstract:

SFE-GC system is established for flavonols assessment.

Optimal parameters of SFE-GC are evaluated and determined.

Quercetin and kaempferol are detected in plant under heavy metal stress.

Gene expression analysis shows consistent regularity with content of flavonols.

ROS level is applied for elaborating the plant resistance status.

Keywords： Flavonols     Heavy metal     Supercritical carbon dioxide extraction (SFE)     GC     Plant resistance    

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Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 2, doi: 10.1007/s11783-019-1212-6

Abstract: • Fuel consumption (FC) from LDPVs is measured using on-board diagnostic method (OBD). • The FC ofThe on-board diagnostic (OBD) approach, which is flexible and offers high-resolution data collection,

Keywords： Fuel consumption     Light-duty passenger vehicles     On-board diagnostic systems    

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Intelligent fault diagnostic system based on RBR for the gearbox of rolling mills

Lixin GAO, Lijuan WU, Yan WANG, Houpei WEI, Hui YE

Frontiers of Mechanical Engineering 2010, Volume 5, Issue 4,   Pages 483-490 doi: 10.1007/s11465-010-0118-6

Abstract: This paper presents an intelligent system that is necessary for diagnostic accuracy and efficiency inA rule-based reseaning (RBR) intelligent diagnostic system has been developed based on many successfuldiagnostic applications.

Keywords： rule-based reasoning     fault diagnosis     intelligent system     gear box    

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Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 1-3 doi: 10.1007/s11705-021-2134-y

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Title Author Date Type Operation

Molecular authentication of the traditional Chinese medicine Tongren Dahuoluo Wan and its alternative

Jikun WANG, Jing DU, Meng CAO, Lu YAO, Suhua XIE, Jiafu CHEN, Xingbo ZHAO

Journal Article

Biosensor-based assay of exosome biomarker for early diagnosis of cancer

Journal Article

Increased expression of coronin-1a in amyotrophic lateral sclerosis: a potential diagnostic biomarker

Journal Article

Obesity in China: its characteristics, diagnostic criteria, and implications

Weiping Jia

Journal Article

Meta-analysis of the diagnostic efficiency of frequency-doubling technology for primary glaucoma

LIU Ting, HE Xiangge

Journal Article

Development and application of reconfigurable monitoring and diagnostic system oriented to machine tool

Jing Minqing,Li Meng,Liu Heng

Journal Article

Clinical outcomes of ATP-tumor chemosensitivity assay directed chemotherapy in hepatocellular carcinoma

RAO Rongsheng, CHEN Wenxue, ZHOU Xinwen, ZHOU Zheng, LI Xiaojun, ZENG Zhiping

Journal Article

Cloning of human XAF1 gene promoter and assay of its transcription activity in a variety of cell lines

Qiong CHEN, Qing YU, Yuhu SONG, Peiyuan Li, Ying CHANG, Zhijun WANG, Lifeng LIU, Wei WU, Jusheng LIN

Journal Article

An investigation on patient dose in screen-film diagnostic radiology in Lhasa City, Xizang Autonomous

Xiang Du

Journal Article

Diagnostic criteria of latent autoimmune diabetes in adults (LADA): a review and reflection

Yu Liao, Yufei Xiang, Zhiguang Zhou

Journal Article

treatment of reproductive diseases and infertility: an overview from the mechanism to the clinic alongside diagnostic

Journal Article

An extraction- assay system: Evaluation on flavonols in plant resistance to Pb and Cd by supercritical

Xu Zhang, Huanhuan Yang, Xinlei Wang, Wen Song, Zhaojie Cui

Journal Article

Real-world fuel consumption of light-duty passenger vehicles using on-board diagnostic (OBD) systems

Xuan Zheng, Sheng Lu, Liuhanzi Yang, Min Yan, Guangyi Xu, Xiaomeng Wu, Lixin Fu, Ye Wu

Journal Article

Intelligent fault diagnostic system based on RBR for the gearbox of rolling mills

Lixin GAO, Lijuan WU, Yan WANG, Houpei WEI, Hui YE

Journal Article

Special issue on “Molecular Sensors and Molecular Logic Gates”

Luling Wu , Tony D. James

Journal Article